The in-vitro release characteristics of the class II active pharmaceutical ingredients according to Biopharmaceutical classification system are very slightly water soluble. The absorption rate of a poorly water-soluble drug, from the orally administered solid dosage form is controlled by its dissolution rate in the fluid present at the absorption site, i.e. the dissolution rate is often the rate-determining step in drug absorption. Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Different methods are discussed here.
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